CDC23 Antikörper (AA 270-320)

Produktnummer ABIN6991328

Der Kaninchen Polyklonal Anti-CDC23-Antikörper wurde für WB, ELISA und ICC validiert. Er ist geeignet, CDC23 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CDC23 Antikörper (AA 270-320) (ABIN6991328)

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDC23 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Produktdetails anti-CDC23 Antikörper

Bindungsspezifität: AA 270-320

Aufreinigung: APC8 Antibody is affinity chromatography purified via peptide column.

Immunogen: APC8 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC8. The immunogen is located within amino acids 270 - 320 of APC8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: APC8 antibody can be used for detection of APC8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: APC8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: APC8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CDC23

Target: CDC23 (Cell Division Cycle 23 (CDC23))

Andere Bezeichnung: APC8

Hintergrund: APC8 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC8 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. In Drosophila, silencing of APC8 results in developmental delay and pupal lethality with elevated levels of apoptosis, high mitotic index, and delayed or blocked mitosis.

Gen-ID: 8697

UniProt: Q9UJX2

Pathways: Protein targeting to Nucleus