PALB2 Antikörper (C-Term)

Produktnummer ABIN6991161

Dieses Anti-PALB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PALB2 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für PALB2 Antikörper (C-Term) (ABIN6991161)

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PALB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-PALB2 Antikörper

Bindungsspezifität: AA 940-990, C-Term

Spezifität: At least four isoforms of PALB2 are known to exist, this antibody will detect all four isoforms.

Aufreinigung: PALB2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2. The immunogen is located within amino acids 940 - 990 of PALB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PALB2 antibody can be used for detection of PALB2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PALB2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PALB2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PALB2

Target: PALB2 (Partner and Localizer of BRCA2 (PALB2))

Andere Bezeichnung: PALB2

Hintergrund: PALB2 Antibody: The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments.

Molekulargewicht: Predicted: 65, 100, 130 kDa

Observed: 140 kDa

Gen-ID: 79728

UniProt: Q86YC2

Pathways: DNA Reparatur