GLE1 Antikörper (AA 390-440)

Produktnummer ABIN6991041

Dieses Anti-GLE1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GLE1 in WB, ELISA, IF und IHC (p). Geeignet für Human, Ratte und Maus.

Kurzübersicht für GLE1 Antikörper (AA 390-440) (ABIN6991041)

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GLE1 Antikörper

Bindungsspezifität: AA 390-440

Aufreinigung: Gle1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Gle1 antibody was raised against a 14 amino acid synthetic peptide near the center of human Gle1. The immunogen is located within amino acids 390 - 440 of Gle1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Gle1 antibody can be used for detection of Gle1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Gle1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Gle1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Andere Bezeichnung: Gle1

Hintergrund: Gle1 Antibody: The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist.

Gen-ID: 2733

NCBI Accession: NP_001003722

UniProt: Q53GS7