TREX1 Antikörper (AA 220-270)

Produktnummer ABIN6991039

Produktdetails anti-TREX1 Antikörper

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Bindungsspezifität: AA 220-270

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TREX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TREX1 antibody will not cross-react with the related protein TREX2. At least three isoforms of TREX1 are known to exist, this antibody will recognize all three isoforms.

Aufreinigung: TREX1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TREX1 antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1. The immunogen is located within amino acids 220 - 270 of TREX1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TREX1 antibody can be used for detection of TREX1 by Western blot at 0.5 and 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TREX1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TREX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Andere Bezeichnung: TREX1 (TREX1 Produkte)

Synonyme: AGS1 antikoerper, CRV antikoerper, DRN3 antikoerper, HERNS antikoerper, 1661 antikoerper, AU041952 antikoerper, RGD1309596 antikoerper, three prime repair exonuclease 1 antikoerper, CpipJ_CPIJ012074 antikoerper, Tsp_03749 antikoerper, TREX1 antikoerper, Trex1 antikoerper

Hintergrund: TREX1 Antibody: Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

Molekulargewicht: Predicted: 33, 35, 41 kDa

Observed: 31 kDa

Gen-ID: 11277

NCBI Accession: NP_057465

UniProt: Q9NSU2

Pathways: Apoptose