DISP2 Antikörper (N-Term)

Produktnummer ABIN6991015

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DISP2 in ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für DISP2 Antikörper (N-Term) (ABIN6991015)

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DISP2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-DISP2 Antikörper

Bindungsspezifität: AA 110-160, N-Term

Spezifität: DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.

Aufreinigung: DISP2 Antibody is affinity chromatography purified via peptide column.

Immunogen: DISP2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DISP2. The immunogen is located within amino acids 110 - 160 of DISP2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: DISP2 antibody can be used for detection of DISP2 by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: DISP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: DISP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Andere Bezeichnung: DISP2

Hintergrund: DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

Gen-ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signalweg