STK39 Antikörper (AA 360-410)

Produktnummer ABIN6991004

Der Kaninchen Polyklonal Anti-STK39-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, STK39 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für STK39 Antikörper (AA 360-410) (ABIN6991004)

Target: STK39 (serine threonine Kinase 39 (STK39))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK39 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-STK39 Antikörper

Bindungsspezifität: AA 360-410

Aufreinigung: Stk39 Antibody is affinity chromatography purified via peptide column.

Immunogen: Stk39 antibody was raised against a 18 amino acid synthetic peptide from near the center of human Stk39. The immunogen is located within amino acids 360 - 410 of Stk39.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Stk39 antibody can be used for detection of Stk39 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in rat samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Stk39 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Stk39 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu STK39

Target: STK39 (serine threonine Kinase 39 (STK39))

Andere Bezeichnung: Stk39

Hintergrund: Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

Gen-ID: 27347

NCBI Accession: NP_037365

UniProt: Q9UEW8