IL-34 Antikörper (AA 60-110)

Produktnummer ABIN6990970

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch IL-34 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für IL-34 Antikörper (AA 60-110) (ABIN6990970)

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL-34 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-IL-34 Antikörper

Bindungsspezifität: AA 60-110

Aufreinigung: IL-34 Antibody is affinity chromatography purified via peptide column.

Immunogen: IL-34 antibody was raised against a 13 amino acid synthetic peptide from near the center of human IL-34. The immunogen is located within amino acids 60 - 110 of IL-34.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IL-34 antibody can be used for the detection of IL-34 by Western blot at 0.25 μ,g/mL. Despite its predicted molecular weight, IL-34 will often run at higher molecular weight in SDS-PAGE.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: IL-34 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: IL-34 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu IL-34

Target: IL-34 (IL34) (Interleukin 34 (IL34))

Andere Bezeichnung: IL-34

Hintergrund: IL-34 Antibody: Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages.

Molekulargewicht: Predicted: 26 kDa

Observed: 42-48 kDa 

Gen-ID: 146433

UniProt: Q6ZMJ4

Pathways: RTK Signalweg