GP6 Antikörper (AA 130-180)

Produktnummer ABIN6990966

Dieses Anti-GP6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GP6 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für GP6 Antikörper (AA 130-180) (ABIN6990966)

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-GP6 Antikörper

Bindungsspezifität: AA 130-180

Aufreinigung: GPVI Antibody is affinity chromatography purified via peptide column.

Immunogen: GPVI antibody was raised against a 18 amino acid synthetic peptide near the center of the human GPVI. The immunogen is located within amino acids 130 - 180 of GPVI.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: GPVI antibody can be used for detection of GPVI by Western blot at 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: GPVI Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: GPVI antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GP6

Target: GP6 (Glycoprotein VI (Platelet) (GP6))

Andere Bezeichnung: GPVI

Hintergrund: GPVI Antibody: Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcRgamma) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcRgamma, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.

Molekulargewicht: Predicted: 37, 68 kDa

Observed: 55 kDa 

Gen-ID: 51206

NCBI Accession: NP_057447

UniProt: Q9HCN6