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GP6 Antikörper (C-Term)

GP6 Reaktivität: Human, Maus, Ratte WB, IHC (p), IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499916
  • Target Alle GP6 Antikörper anzeigen
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Bindungsspezifität
    • 15
    • 13
    • 8
    • 5
    • 3
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 46
    • 1
    Kaninchen
    Klonalität
    • 45
    • 1
    • 1
    Polyklonal
    Konjugat
    • 12
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GP6 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 18
    • 13
    • 13
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody reacts to GPVI.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    GPVI antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human GPVI.
    Isotyp
    IgG
    Top Product
    Discover our top product GP6 Primärantikörper
  • Applikationshinweise
    ELISA. Western Blot: 1 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    GP6 (Glycoprotein VI (Platelet) (GP6))
    Andere Bezeichnung
    Platelet Glycoprotein VI (GP6 Produkte)
    Synonyme
    BDPLT11 antikoerper, GPIV antikoerper, GPVI antikoerper, 9830166G18Rik antikoerper, Gm469 antikoerper, Gpvi antikoerper, GP6 antikoerper, glycoprotein VI platelet antikoerper, glycoprotein 6 (platelet) antikoerper, glycoprotein VI antikoerper, platelet glycoprotein VI antikoerper, GP6 antikoerper, Gp6 antikoerper, LOC103346235 antikoerper
    Hintergrund
    Glycoprotein VI (GP6) is a 58kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. It is uniquely expressed by cells of the megakaryocytic/platelet lineage, and is a member of the immunoglobulin gene superfamily, closely related to Fc receptor gamma chain (FcR) and natural killer receptors. Glycoprotein VI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. GPVI deficiency can result in bleeding disorders. Further study should reveal the extent of GPVI involvement in thrombotic disease and allow the development of alternative anti-thrombotic compounds.Synonyms: GP6, GPVI, Glycoprotein 6
    Gen-ID
    51206
    NCBI Accession
    NP_057447
    UniProt
    Q9HCN6
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