Beclin 1 Antikörper (N-Term)

Produktnummer ABIN6990803

Produktdetails anti-Beclin 1 Antikörper

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Bindungsspezifität: AA 40-90, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Beclin 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Aufreinigung: Beclin-1 Antibody is affinity chromatography purified via peptide column.

Immunogen: Beclin-1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Beclin-1. The immunogen is located within amino acids 40 - 90 of Beclin-1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Beclin-1 antibody can be used for the detection of Beclin-1 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in human, mouse, and rat samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Beclin-1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Beclin-1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Andere Bezeichnung: Beclin-1 (BECN1 Produkte)

Synonyme: beclin-1 antikoerper, atg6 antikoerper, vps30 antikoerper, beclin1 antikoerper, Beclin-1 antikoerper, becn1 antikoerper, zgc:73097 antikoerper, ATG6 antikoerper, VPS30 antikoerper, 4921513J16Rik antikoerper, 5430417M23Rik antikoerper, Atg6 antikoerper, beclin 1 antikoerper, beclin 1, autophagy related antikoerper, beclin 1 protein antikoerper, beclin-1 antikoerper, beclin family protein antikoerper, beclin 1, autophagy related L homeolog antikoerper, BECN1 antikoerper, becn1 antikoerper, atg6 antikoerper, CpipJ_CPIJ011087 antikoerper, PTRG_07825 antikoerper, SJAG_01876 antikoerper, Becn1 antikoerper, becn1.L antikoerper

Hintergrund: Beclin-1 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein, which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

Gen-ID: 8678

UniProt: Q14457

Pathways: Autophagie