PEN2 Antikörper (C-Term)

Produktnummer ABIN6990689

Der Kaninchen Polyklonal Anti-PEN2-Antikörper wurde für WB, ELISA und IF validiert. Er ist geeignet, PEN2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PEN2 Antikörper (C-Term) (ABIN6990689)

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PEN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-PEN2 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: PEN2 Antibody is affinity chromatography purified via peptide column.

Immunogen: PEN2 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human PEN2. The immunogen is located within the last 50 amino acids of PEN2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PEN2 antibody can be used for detection of PEN2 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PEN2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PEN2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PEN2

Target: PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))

Andere Bezeichnung: PEN2

Hintergrund: PEN2 Antibody: PEN2, in addition to presenilin, nicastrin, and APH-1 forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimer's disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer's disease.

Gen-ID: 55851

NCBI Accession: NP_758844

UniProt: Q9NZ42

Pathways: Notch Signalweg, Neurotrophin Signalübertragung