AES Antikörper (C-Term)
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- Target Alle AES Antikörper anzeigen
- AES (Amino-terminal Enhancer of Split (AES))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser AES Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Aufreinigung
- AES Antibody is affinity chromatography purified via peptide column.
- Immunogen
- AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES. The immunogen is located within the last 50 amino acids of AES.
- Isotyp
- IgG
- Top Product
- Discover our top product AES Primärantikörper
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- Applikationshinweise
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AES antibody can be used for the detection of AES by Western blot at 1 - 4 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- AES Antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,4 °C
- Informationen zur Lagerung
- AES antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- AES (Amino-terminal Enhancer of Split (AES))
- Andere Bezeichnung
- AES (AES Produkte)
- Synonyme
- AES-1 antikoerper, AES-2 antikoerper, ESP1 antikoerper, GRG antikoerper, GRG5 antikoerper, TLE5 antikoerper, AL024115 antikoerper, Esp1 antikoerper, Grg antikoerper, Grg-5 antikoerper, Grg5 antikoerper, Tle5 antikoerper, zgc:64216 antikoerper, aes-1 antikoerper, aes-2 antikoerper, esp1 antikoerper, grg antikoerper, grg5 antikoerper, tle5 antikoerper, xgrg-5 antikoerper, AES antikoerper, amino-terminal enhancer of split antikoerper, amino-terminal enhancer of split S homeolog antikoerper, AES antikoerper, Aes antikoerper, aes antikoerper, aes.S antikoerper
- Hintergrund
- AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
- Gen-ID
- 166
- NCBI Accession
- NP_945320
- UniProt
- Q08117
- Pathways
- WNT Signalweg, SARS-CoV-2 Protein Interaktom
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