ECSIT Antikörper (C-Term)

Produktnummer ABIN6990485

Der Kaninchen Polyklonal Anti-ECSIT-Antikörper wurde für WB, ELISA und IHC (p) validiert. Er ist geeignet, ECSIT in Proben von Human und Maus zu detektieren.

Kurzübersicht für ECSIT Antikörper (C-Term) (ABIN6990485)

Target: ECSIT

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ECSIT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ECSIT Antikörper

Bindungsspezifität: AA 290-340, C-Term

Aufreinigung: ECSIT Antibody is Ion exchange chromatography purified.

Immunogen: ECSIT antibody was raised against a peptide corresponding to 14 amino acids near the C-terminus of human ECSIT. The immunogen is located within amino acids 290 - 340 of ECSIT.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ECSIT antibody can be used for detection of ECSIT by Western blot at 0.5 to 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ECSIT Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ECSIT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ECSIT

Target: ECSIT

Andere Bezeichnung: ECSIT

Hintergrund: ECSIT Antibody: Activation of NF-κ,B as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

Gen-ID: 51295

NCBI Accession: NP_057665

UniProt: Q9BQ95

Pathways: TLR Signalweg, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interaktom