BIRC6 Antikörper (C-Term)

Produktnummer ABIN6990463

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BIRC6 in ELISA und IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für BIRC6 Antikörper (C-Term) (ABIN6990463)

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BIRC6 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-BIRC6 Antikörper

Bindungsspezifität: AA 4760-4810, C-Term

Spezifität: BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

Aufreinigung: BRUCE Antibody is affinity chromatography purified via peptide column.

Immunogen: BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μ,g/mL.

Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: BRUCE Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu BIRC6

Target: BIRC6 (Baculoviral IAP Repeat-Containing 6 (BIRC6))

Andere Bezeichnung: BRUCE

Hintergrund: BRUCE Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Molekulargewicht: 534 kDa

Gen-ID: 57448

NCBI Accession: NP_057336

UniProt: Q9NR09