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CARD10 Antikörper (N-Term)

Dieses Anti-CARD10-Antikörper ist ein Rabbit Polyclonal-Antikörper zur Detektion von CARD10 in ELISA, IHC (p). Geeignet für Human.
Produktnummer ABIN6990438

Kurzübersicht für CARD10 Antikörper (N-Term) (ABIN6990438)

Target

Alle CARD10 Antikörper anzeigen
CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

Reaktivität

  • 29
  • 7
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 29
  • 1
Kaninchen

Klonalität

  • 29
  • 1
Polyklonal

Konjugat

  • 18
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CARD10 Antikörper ist unkonjugiert

Applikation

  • 19
  • 14
  • 6
  • 6
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 7
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term

    Spezifität

    CARMA3 antibody is human specific. At least three isoforms of CARMA3 are known to exist, this antibody will only detect isoform 1. CARMA3 antibody is predicted not to cross-react with other CARMA proteins.

    Aufreinigung

    CARMA3 Antibody is affinity chromatography purified via peptide column.

    Immunogen

    CARMA3 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CARMA3. The immunogen is located within the first 50 amino acids of CARMA3.

    Isotyp

    IgG
  • Applikationshinweise

    CARMA3 antibody can be used for detection of CARMA3 by immunohistochemistry at 5 μ,g/mL.

    Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 mg/mL

    Buffer

    CARMA3 Antibody is supplied in PBS containing 0.02 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C,4 °C

    Informationen zur Lagerung

    CARMA3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target

    CARD10 (Caspase Recruitment Domain Family, Member 10 (CARD10))

    Andere Bezeichnung

    CARMA3

    Hintergrund

    CARMA3 Antibody: CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κ,B activation. When expressed in cells, this protein binds to BCL10 and activates NF-κ,B Recent experiments have shown that CARMA3 is required for EGF-induced NF-κ,B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.

    Gen-ID

    29775

    NCBI Accession

    NP_055365

    UniProt

    Q9BWT7

    Pathways

    S100 Proteine
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