CARD8 Antikörper (C-Term)

Produktnummer ABIN6990435

Dieses Anti-CARD8-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CARD8 in WB, ELISA, IF und ICC. Geeignet für Human.

Kurzübersicht für CARD8 Antikörper (C-Term) (ABIN6990435)

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARD8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-CARD8 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: CARD8 Antibody is affinity chromatography purified via peptide column.

Immunogen: CARD8 antibody was raised against a synthetic peptide corresponding to amino acids at the C-terminus of human CARD8. The immunogen is located within the last 50 amino acids of CARD8.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CARD8 antibody can be used for detection of CARD8 by Western blot at 1 -2 μ,g/mL. An approximate 45 kDa can be detected. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CARD8 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CARD8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CARD8

Target: CARD8 (Caspase Recruitment Domain Family, Member 8 (CARD8))

Andere Bezeichnung: CARD8

Hintergrund: CARD8 Antibody: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, BCL-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD8. This protein interacts with DRAL, a p53-responsive protein implicated in the induction of apoptosis, and caspase-1 and its related proteins ICEBERG and pesudo-ICE. Although there are conflicting reports on whether CARD8 acts a pro- or anti-apoptotic protein, it has been suggested that it functions as an adaptor molecule regulating caspase-1 and NF-κ,B activation.

Molekulargewicht: Predicted: 47 kDa

Observed: 47 kDa

Gen-ID: 22900

UniProt: Q9Y2G2

Pathways: Positive Regulation of Endopeptidase Activity