FAIM3 Antikörper (C-Term)

Produktnummer ABIN6990337

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FAIM3 in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FAIM3 Antikörper (C-Term) (ABIN6990337)

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FAIM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-FAIM3 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Toso Antibody is affinity chromatography purified via peptide column.

Immunogen: Toso antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Toso. The immunogen is located within the first 50 amino acids of Toso.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Toso antibody can be used for detection of Toso by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Toso Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Toso antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu FAIM3

Target: FAIM3 (Fas Apoptotic Inhibitory Molecule 3 (FAIM3))

Andere Bezeichnung: Toso

Hintergrund: Toso Antibody: Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

Molekulargewicht: Predicted: 43 kDa

Observed: 41 kDa

Gen-ID: 9214

NCBI Accession: NP_005440

UniProt: O60667