MAP3K14 Antikörper (C-Term)

Produktnummer ABIN6990248

Der Kaninchen Polyklonal Anti-MAP3K14-Antikörper wurde für WB, ELISA, IF und ICC validiert. Er ist geeignet, MAP3K14 in Proben von Human zu detektieren.

Kurzübersicht für MAP3K14 Antikörper (C-Term) (ABIN6990248)

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP3K14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Produktdetails anti-MAP3K14 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: NIK Antibody is affinity chromatography purified via peptide column.

Immunogen: NIK antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NIK. The immunogen is located within the last 50 amino acids of NIK.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: NIK antibody can be used for detection of NIK by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: NIK Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: NIK antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu MAP3K14

Target: MAP3K14 (Mitogen-Activated Protein Kinase Kinase Kinase 14 (MAP3K14))

Andere Bezeichnung: NIK

Hintergrund: NIK Antibody: Nuclear factor kappa B (NF-κ,B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ,B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, LPS and mitogens. A serine/threonine protein kinase which mediates NF-κ,B activation by IL-1, TNFα, and CD95 was identified recently and designated NIK (for NF-κ,B inducing kinase). NIK is an activator of Iκ,B kinase alpha and beta (IKKα, and IKKβ,). Therefore, NIK is a key molecule in the NF-κ,B signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

Molekulargewicht: Predicted: 104 kDa

Gen-ID: 9020

UniProt: Q99558

Pathways: NF-kappaB Signalweg, T-Zell Rezeptor Signalweg