PD-L1 Antikörper (Extracellular Domain)

Produktnummer ABIN6990233

Der Maus Monoklonal Anti-PD-L1-Antikörper wurde für WB, ELISA, IF, ICC und IHC (p) validiert. Er ist geeignet, PD-L1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für PD-L1 Antikörper (Extracellular Domain) (ABIN6990233)

Target: PD-L1 (CD274 (PD-L1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PD-L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 6H10

Produktdetails anti-PD-L1 Antikörper

Bindungsspezifität: Extracellular Domain

Spezifität: PD-L1 Antibody has no cross-reactivity to PD-L2.

Aufreinigung: PD-L1 Antibody is supplied as protein A purified IgG1.

Immunogen: Anti-PD-L1 antibody was raised against the extracellular domain of human PD-L1.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 0.25 - 4 μ,g/mL, IF: 2 μ,g/mL, IHC-P: 5 μ,g/mL, ICC: 1 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples, Immunohistochemistry, Immunocytochemistry and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PD-L1 Antibody is supplied in PBS containing 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PD-L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PD-L1

Target: PD-L1 (CD274 (PD-L1))

Andere Bezeichnung: PDL1

Hintergrund: PD-L1 plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/CD279, PD-L1 modulates the activation threshold of T-cells and limits T-cell effector response (1). The PDCD1/CD279-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (2,3). Through a yet unknown activating receptor, it may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) (4).

Molekulargewicht: Predicted: 33kD

Observed: 37kD kDa

Gen-ID: 29126

NCBI Accession: NP_054862

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints