Vinculin Antikörper (N-Term)

Produktnummer ABIN6990230

Produktdetails anti-Vinculin Antikörper

Target: Vinculin (VCL)

Bindungsspezifität: AA 50-100, N-Term

Reaktivität: Human, Maus, Ratte, Kaninchen, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Vinculin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Vinculin antibody is human, mouse, rat, rabbit and chicken reactive. At least three isoforms of Vinculin are known to exist.

Aufreinigung: Vinculin antibody is purified via Protein A prification.

Immunogen: Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin. The immunogen is located within amino acids 50 - 100 of Vinculin.

Klon: 7E10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Vinculin antibody can be used for detection of Vinculin by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human, mouse, and rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Vinculin Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Vinculin antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu Vinculin

Target: Vinculin (VCL)

Andere Bezeichnung: Vinculin (VCL Produkte)

Synonyme: CMD1W antikoerper, CMH15 antikoerper, MV antikoerper, MVCL antikoerper, VCL antikoerper, im:6902790 antikoerper, hm:zehn2160 antikoerper, DDBDRAFT_0186762 antikoerper, DDBDRAFT_0232320 antikoerper, DDB_0186762 antikoerper, DDB_0232320 antikoerper, 9430097D22 antikoerper, AA571387 antikoerper, AI462105 antikoerper, AW545629 antikoerper, CG3299 antikoerper, CT11081 antikoerper, Dmel\\CG3299 antikoerper, Dmvincp antikoerper, EG:103B4.1 antikoerper, Vin antikoerper, Vin2EF antikoerper, vinc antikoerper, LOC100228062 antikoerper, vcl-A antikoerper, vinculin antikoerper, vinculin a antikoerper, vinculin A antikoerper, Vinculin antikoerper, vinculin S homeolog antikoerper, VCL antikoerper, vcla antikoerper, vinA antikoerper, Vcl antikoerper, Vinc antikoerper, CpipJ_CPIJ013873 antikoerper, Bm1_37935 antikoerper, vcl antikoerper, vcl.S antikoerper

Hintergrund: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).

Molekulargewicht: Predicted: 117 kDa

Observed: 120 kDa

Gen-ID: 7414

NCBI Accession: NP_003364

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2