PUMA Antikörper (AA 76-170)
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- Target Alle PUMA (BBC3) Antikörper anzeigen
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
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Bindungsspezifität
- AA 76-170
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser PUMA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Immunogen
- Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
- Klon
- 2A9G5
- Isotyp
- IgG1
- Top Product
- Discover our top product BBC3 Primärantikörper
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anti-BCL2 Binding Component 3 (BBC3) antibody
BBC3 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Monoclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibodyBBC3 Reaktivität: Human WB, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 131-180) antibodyBBC3 Reaktivität: Human, Ratte, Schwein WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reaktivität: Human WB, FACS, IHC (p), IF Wirt: Kaninchen Polyclonal RB01353 unconjugated
anti-BCL2 Binding Component 3 (BBC3) (AA 119-154) antibodyBBC3 Reaktivität: Human WB, ELISA, IHC, FACS, IF Wirt: Kaninchen Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibodyBBC3 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PE)BBC3 Reaktivität: Human WB, ICC, IF Wirt: Kaninchen Polyclonal PE
anti-BCL2 Binding Component 3 (BBC3) (C-Term) antibody (PerCP)BBC3 Reaktivität: Human WB, ICC, IF Wirt: Kaninchen Polyclonal PerCP
anti-BCL2 Binding Component 3 (BBC3) (N-Term) antibody (Biotin)BBC3 Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal Biotin
anti-BCL2 Binding Component 3 (BBC3) (BH3 Domain), (C-Term) antibodyBBC3 Reaktivität: Human, Maus WB, FACS, IHC (p), IF, EIA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 μ,g/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PUMA Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- PUMA monoclonal antibody can be stored at -20°C, stable for one year.
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- Target
- PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))
- Andere Bezeichnung
- PUMA (BBC3 Produkte)
- Synonyme
- BBC3 antikoerper, Puma antikoerper, JFY-1 antikoerper, JFY1 antikoerper, PUMA antikoerper, PUMA/JFY1 antikoerper, BCL2 binding component 3 antikoerper, Bcl-2 binding component 3 antikoerper, BBC3 antikoerper, Bbc3 antikoerper, bbc3 antikoerper
- Hintergrund
- PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα, and PUMAβ,. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
- Gen-ID
- 27113
- UniProt
- Q9BXH1
- Pathways
- p53 Signalweg, Positive Regulation of Endopeptidase Activity
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