PUMA Antikörper (AA 76-170)

Produktnummer ABIN6990174

Dieses Anti-PUMA-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von PUMA in WB und ELISA. Geeignet für Human, Ratte und Maus.

Kurzübersicht für PUMA Antikörper (AA 76-170) (ABIN6990174)

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PUMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 2A9G5

Produktdetails anti-PUMA Antikörper

Bindungsspezifität: AA 76-170

Aufreinigung: PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Immunogen: Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: PUMA antibody can be used for detection of PUMA by Western blot at 2.5 to 5 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PUMA Monoclonal Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: PUMA monoclonal antibody can be stored at -20°C, stable for one year.

Details zu PUMA

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Andere Bezeichnung: PUMA

Hintergrund: PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα, and PUMAβ,. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Gen-ID: 27113

UniProt: Q9BXH1

Pathways: p53 Signalweg, Positive Regulation of Endopeptidase Activity