RAC1+CDC42 (pSer71) Antikörper

Produktnummer ABIN6989963

Der Kaninchen Monoklonal anti-RAC1+CDC42 Antikörper wird verwendet zum Nachweis von RAC1+CDC42 in Proben von Human. Er wurde validiert für WB, IHC, IF (cc) und IHC (p).

Kurzübersicht für RAC1+CDC42 (pSer71) Antikörper (ABIN6989963)

Target: RAC1+CDC42

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 5H1

Produktdetails

Bindungsspezifität: pSer71

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic phospho-Peptide corresponding to residues surrounding Ser71 of human CDC42.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Antigendetails

Target: RAC1+CDC42

Hintergrund:

Synonyms: CDC42Hs antibody, Cell division cycle 42 antibody, G25K antibody, MIG5 antibody, Migration inducing gene 5 antibody, p21 Rac1 antibody, Ras like protein TC25 antibody, Small GTP binding protein Cdc42 antibody, TC25 antibody

Background: The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013].

Gen-ID: 998

UniProt: P60953

Pathways: WNT Signalweg