ALKBH5 Antikörper (AA 1-100)

Produktnummer ABIN6989272

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ALKBH5 in ELISA, IF (cc), IF (p), IHC (p), IHC (fro) und ICC. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für ALKBH5 Antikörper (AA 1-100) (ABIN6989272)

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH5 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Produktdetails anti-ALKBH5 Antikörper

Bindungsspezifität: AA 1-100

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ALKBH5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ALKBH5

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Andere Bezeichnung: ALKBH5

Hintergrund:

Synonyms: ABH5, AlkB, alkylation repair homolog 5 (E. coli), AlkB, alkylation repair homolog 5, Alkylated DNA repair protein alkB homolog 5, Alpha ketoglutarate dependent dioxygenase alkB homolog 5, OFOXD, OFOXD1, Oxoglutarate and iron-dependent oxygenase domain containing, Probable alpha ketoglutarate dependent dioxygenase ABH5, RNA demethylase ALKBH5.

Background: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A)RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro)(PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178,PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

Gen-ID: 54890

UniProt: Q6P6C2