ALKBH5 Antikörper (AA 245-394)
Kurzübersicht für ALKBH5 Antikörper (AA 245-394) (ABIN6136806)
Target
Alle ALKBH5 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 245-394
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Sequenz
- SLPVRRGSVT VLSGYAADEI THCIRPQDIK ERRAVIILRK TRLDAPRLET KSLSSSVLPP SYASDRLSGN NRDPALKPKR SHRKADPDAA HRPRILEMDK EENRRSVLLP THRRRGSFSS ENYWRKSYES SEDCSEAAGS PARKVKMRRH
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Kreuzreaktivität
- Human, Maus, Ratte
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Produktmerkmale
- Polyclonal Antibodies
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 245-394 of human ALKBH5 (NP_060228.3).
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Isotyp
- IgG
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Applikationshinweise
- WB,1:500 - 1:2000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))
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Andere Bezeichnung
- ALKBH5
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Hintergrund
- Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6-methyladenosine (m6A RNA, the most prevalent internal modification of messenger RNA (mRNA in higher eukaryotes. Can also demethylate N(6-methyladenosine in single-stranded DNA (in vitro. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA processing and export. Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes and round spermatids: m6A demethylation of target transcripts is required for correct splicing and the production of longer 3'-UTR mRNAs in male germ cells (By similarity.,ALKBH5,ABH5,OFOXD,OFOXD1,Epigenetics & Nuclear Signaling,DNA Damage & Repair,RNA Binding,ALKBH5
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Molekulargewicht
- 43 kDa/44 kDa/52 kDa
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Gen-ID
- 54890
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UniProt
- Q6P6C2
Target
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