C5 Antikörper (AA 51-150) (Biotin)

Produktnummer ABIN6982559

Der Kaninchen Polyklonal Anti-C5-Antikörper wurde für ELISA, IHC (p) und IHC (fro) validiert. Er ist geeignet, C5 in Proben von Human zu detektieren.

Kurzübersicht für C5 Antikörper (AA 51-150) (Biotin) (ABIN6982559)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C5 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-C5 Antikörper (Biotin)

Bindungsspezifität: AA 51-150

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Complement C5 beta chain

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: Complement C5 beta chain

Hintergrund:

Synonyms: Anaphylatoxin C5a, C5, Complement C5, Complement C5 precursor, Complement component 5, CPAMD4, CO5_HUMAN.

Background: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Gen-ID: 727

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis