SLC8A1 Antikörper (AA 801-900) (AbBy Fluor® 680)

Produktnummer ABIN6980858

Der Kaninchen Polyklonal anti-SLC8A1 Antikörper wird verwendet zum Nachweis von SLC8A1 in Proben von Human, Ratte und Maus. Er wurde validiert für WB, FACS, IF (cc) und IF (p).

Kurzübersicht für SLC8A1 Antikörper (AA 801-900) (AbBy Fluor® 680) (ABIN6980858)

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC8A1 Antikörper ist konjugiert mit AbBy Fluor® 680

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-SLC8A1 Antikörper (AbBy Fluor® 680)

Bindungsspezifität: AA 801-900

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Sheep,Pig,Horse,Chicken,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NCX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SLC8A1

Target: SLC8A1 (Solute Carrier Family 8 (Sodium/calcium Exchanger), Member 1 (SLC8A1))

Andere Bezeichnung: NCX1/SLC8A1

Hintergrund:

Synonyms: Na+/Ca2+exchanger 1, CNC, DKFZp779F0871, MGC119581 , FLJ37694, FLJ43417, Na+/Ca2+ exchange protein 1, Na+/Ca2+ exchanger, NCX 1, NCX, SLC8A1, SLC8A1 protein , Sodium Calcium Exchanger, Sodium/calcium exchanger 1, Solute carrier family 8 member 1.

Background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma(plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM].

Gen-ID: 6546

Pathways: Myometrial Relaxation and Contraction