ERO1L Antikörper (AA 321-420) (AbBy Fluor® 350)

Produktnummer ABIN6976402

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ERO1L in WB und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ERO1L Antikörper (AA 321-420) (AbBy Fluor® 350) (ABIN6976402)

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERO1L Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-ERO1L Antikörper (AbBy Fluor® 350)

Bindungsspezifität: AA 321-420

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ERO1L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ERO1L

Target: ERO1L (ERO1-Like Protein alpha (ERO1L))

Andere Bezeichnung: ERO1L

Hintergrund:

Synonyms: ERO1-like protein alpha, ERO1A, ERO1-L, ERO1-L-alpha, Endoplasmic oxidoreductin-1-like protein, Endoplasmic reticulum oxidoreductase alpha, Oxidoreductin-1-L-alpha, ERO1L

Background: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

Gen-ID: 30001

UniProt: Q96HE7

Pathways: Peptide Hormone Metabolism, ER-Nucleus Signaling, Brown Fat Cell Differentiation