Ubinuclein 1 Antikörper (AA 1-345)

Produktnummer ABIN6972900

Der Kaninchen Polyklonal Anti-Ubinuclein 1-Antikörper wurde für WB validiert. Er ist geeignet, Ubinuclein 1 in Proben von Human zu detektieren.

Kurzübersicht für Ubinuclein 1 Antikörper (AA 1-345) (ABIN6972900)

Target: Ubinuclein 1 (UBN1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubinuclein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Ubinuclein 1 Antikörper

Bindungsspezifität: AA 1-345

Produktmerkmale: UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis. Ubn1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu Ubinuclein 1

Target: Ubinuclein 1 (UBN1)

Andere Bezeichnung: Ubn1

Molekulargewicht: 145 kDa

NCBI Accession: NP_001072982