Ubinuclein 1 Antikörper (AA 161-210)

Produktnummer ABIN1534139

Der Kaninchen Polyklonal anti-Ubinuclein 1 Antikörper (ABIN1534139) detektiert spezifisch Ubinuclein 1 in WB, ELISA, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für Ubinuclein 1 Antikörper (AA 161-210) (ABIN1534139)

Target: Ubinuclein 1 (UBN1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Ubinuclein 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Ubinuclein 1 Antikörper

Bindungsspezifität: AA 161-210

Verwendungszweck: UBN-1 Antibody

Spezifität: UBN-1 Polyclonal Antibody detects endogenous levels of UBN-1 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu Ubinuclein 1

Target: Ubinuclein 1 (UBN1)

Hintergrund:

Synonyms: UBN1, Ubinuclein-1, HIRA-binding protein, Protein VT4, Ubiquitously expressed nuclear protein

Background: function:Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.,similarity:Belongs to the ubinuclein family.,subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.,subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain), the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.,tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines.,

Gene Name: UBN1

Protein Name: Ubinuclein-1

Molekulargewicht: 121 kDa

Gen-ID: 29855

OMIM: 609771

UniProt: Q9NPG3