Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

SMC1A Antikörper (C-Term)

This anti-SMC1A antibody (ABIN6972754) is a Rabbit Polyclonal antibody detecting SMC1A in WB, IP, ChIP-seq. Suitable for Human.
Produktnummer ABIN6972754

Kurzübersicht für SMC1A Antikörper (C-Term) (ABIN6972754)

Target

Alle SMC1A Antikörper anzeigen
SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

Reaktivität

  • 135
  • 57
  • 25
  • 7
  • 7
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 116
  • 14
  • 4
  • 1
Kaninchen

Klonalität

  • 99
  • 36
Polyklonal

Konjugat

  • 72
  • 7
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
Dieser SMC1A Antikörper ist unkonjugiert

Applikation

  • 101
  • 40
  • 31
  • 29
  • 28
  • 23
  • 20
  • 13
  • 11
  • 9
  • 7
  • 5
  • 4
  • 1
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)
  • Bindungsspezifität

    • 27
    • 16
    • 16
    • 14
    • 11
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Produktmerkmale

    The Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. SMC1 has a myosin-like ATPase domain that serves as a molecular motor to help organize chromatin and is part of the cohesin complex that facilitates chromosome cohesion during the cell cycle. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. SMC1 is also involved in DNA damage repair. Subsequent to double strand DNA breaks, SMC1 is phosphorylated by the ATM kinase. Phosphorylated SMC1 is crucial to the successful repair of DNA damage. Defects in SMC1 isoform A are the cause of Cornelia de Lange syndrome type 2, an inherited developmental disorder associated with malformations affecting multiple systems. SMC1-a antibody (pAb) was raised in a Rabbit host. It has been validated for use in ChIP-Seq, Immunoprecipitation and Western blot, it has been shown to react with Human samples.

    Aufreinigung

    Affinity Purified

    Immunogen

    This SMC-α antibody was raised against a peptide within the C-terminal region of human SMC1-α.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target

    SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))

    Andere Bezeichnung

    SMC1-α

    Molekulargewicht

    160 kDa

    NCBI Accession

    NP_006297

    Pathways

    Stem Cell Maintenance
Sie sind hier:
Chat with us!