RAR-alpha (AA 428-441) Antikörper

Produktnummer ABIN6972585

Der Maus Monoklonal anti-RAR-alpha Antikörper wird verwendet zum Nachweis von RAR-alpha in Proben von Human. Er wurde validiert für IHC, SSA und WB.

Kurzübersicht für RAR-alpha (AA 428-441) Antikörper (ABIN6972585)

Target: RAR-alpha

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Immunohistochemistry (IHC), Supershift Assay (SSA), Western Blotting (WB)

Klon: 4gamma-7A11

Produktdetails

Bindungsspezifität: AA 428-441

Produktmerkmale: Retinoic acid receptors (RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-a, RAR-b and RAR-g. RAR-g has two splice isoforms. RAR-g heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein. RAR-gamma antibody (mAb) (Clone 4g-7A11) was raised in a Mouse host. It has been validated for use in Immunohistochemistry, Supershift and Western blot, it has been shown to react with Human samples.

Aufreinigung: Protein G Chromatography

Immunogen: This RAR-γ antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARγ.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Antigendetails

Target: RAR-alpha

Andere Bezeichnung: RAR-γ

Molekulargewicht: 52 kDa

NCBI Accession: NP_000957