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MBD1 Antikörper (C-Term)

Dieses Anti-MBD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MBD1 in WB. Geeignet für Human.
Produktnummer ABIN6972316

Kurzübersicht für MBD1 Antikörper (C-Term) (ABIN6972316)

Target

Alle MBD1 Antikörper anzeigen
MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Reaktivität

  • 57
  • 20
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
Human

Wirt

  • 38
  • 22
Kaninchen

Klonalität

  • 36
  • 24
Polyklonal

Konjugat

  • 34
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MBD1 Antikörper ist unkonjugiert

Applikation

  • 40
  • 23
  • 16
  • 13
  • 13
  • 10
  • 10
  • 5
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Produktmerkmale

    MBD1 (methyl-CpG binding domain protein 1) is thought to function as a mediator of the biological consequences of DNA methylation. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and control of gene expression. It is generally associated with the repressive chromatin state. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins include MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD1 is recruited to both methylated and non-methylated CpGs via separate domains: the CXXC domain targets the protein to non-methylated CpGs whereas the MBD domain targets the protein to methylated CpG. During S phase of the cell cycle, MBD1 can interact with SETDB1 (H3K9 methyltransferase). MBD1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

    Aufreinigung

    Affinity Purified

    Immunogen

    This MBD1 antibody was raised against a peptide within the C-terminal region of human MBD1.

    Isotyp

    IgG
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • Target

    MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

    Andere Bezeichnung

    MBD1

    Molekulargewicht

    80 kDa

    NCBI Accession

    NP_056671
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