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MBD1 Antikörper (N-Term)

MBD1 Reaktivität: Human WB, ELISA, ChIP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6655183
  • Target Alle MBD1 Antikörper anzeigen
    MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
    Bindungsspezifität
    • 15
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 42
    • 19
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 33
    • 9
    Kaninchen
    Klonalität
    • 35
    • 7
    Polyklonal
    Konjugat
    • 24
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MBD1 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 13
    • 13
    • 13
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP)
    Kreuzreaktivität (Details)
    Cross reactivity with other species was not tested.
    Aufreinigung
    Anti-MBD1 Antibody was purified by affinity purification.
    Immunogen

    Immunogen: Anti-MBD1 Antibody was produced in rabbits by repeated immunizations with a synthetic peptide containing a sequence from the N-terminus of human MBD1.

    Immunogen Type: Peptide

    Isotyp
    IgG
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  • Applikationshinweise

    Application Note: Anti-MBD1 Antibody is suitable for Chromatin Immunoprecipitation, ELISA and Western Blots. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 75 kDa in the appropriate cell lysate or extract.

    ChIP Dilution: 1.5 μg per IP

    ELISA Dilution: 1:1,000

    Western Blot Dilution: 1:500

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

    0.05 % (w/v) Sodium Azide and 0.05 % ProClin 300/p>

    Stabilizer: None

    Konservierungsmittel
    ProClin, Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide and ProClin: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Lagerung
    RT,4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Target
    MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))
    Andere Bezeichnung
    MBD1 (MBD1 Produkte)
    Synonyme
    CXXC3 antikoerper, PCM1 antikoerper, RFT antikoerper, Cxxc3 antikoerper, CCDC11 antikoerper, methyl-CpG binding domain protein 1 antikoerper, MBD1 antikoerper, Mbd1 antikoerper
    Hintergrund

    Synonyms: Methyl-CpG-binding domain protein 1, CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, CXXC3, PCM1

    Background: MBD1 is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC's) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription. Anti-MBD1 Antibody is ideal for research in Epigenetics, Gene Expression and Chromatin Remodeling.

    Gene Name: MBD1

    Gen-ID
    4152
    NCBI Accession
    NP_001191065
    UniProt
    Q9UIS9
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