MBD1 Antikörper

Produktnummer ABIN6940006

Der Maus Monoklonal anti-MBD1 Antikörper wird verwendet zum Nachweis von MBD1 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für MBD1 Antikörper (ABIN6940006)

Target: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MBD1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: CPTC-MBD1-1

Produktdetails anti-MBD1 Antikörper

Verwendungszweck: MBD1 (Methyl-CpG Binding Domain Protein 1) Antibody

Spezifität: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant human MBD1 protein

Isotyp: IgG2, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Human tonsil or colon (IHC).

Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu MBD1

Target: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Andere Bezeichnung: MBD1

Hintergrund:

CXXC-type zinc finger protein 3, CXXC3, MBD1, MECP1 COMPLEX, Methyl-CpG-binding domain protein 1 (MBD1), Protein containing methyl-CpG-binding domain 1 (PCM1), Regulator of fibroblast growth factor 2 (FGF 2) transcription (RFT)

Human tonsil or colon (IHC).

Molekulargewicht: ~80kDa

Gen-ID: 4152, 405610

UniProt: Q9UIS9