MAF Antikörper (C-Term)

Produktnummer ABIN6972305

Produktdetails anti-MAF Antikörper

Target: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: MAF (V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog) acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells (By similarity). When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. MAF antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This antibody was raised against a peptide within the C-terminal region of human MAF.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu MAF

Target: MAF (V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) (MAF))

Andere Bezeichnung: MAF (MAF Produkte)

Synonyme: MAF antikoerper, DKFZp459D1731 antikoerper, 2810401A20Rik antikoerper, A230108G15Rik antikoerper, AW047063 antikoerper, c-maf antikoerper, CCA4 antikoerper, c-MAF antikoerper, Maf2 antikoerper, cMaf antikoerper, Z-cmaf antikoerper, c-Maf antikoerper, fl13d12 antikoerper, wu:fl13d12 antikoerper, C-Maf antikoerper, MAF bZIP transcription factor antikoerper, v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) antikoerper, avian musculoaponeurotic fibrosarcoma oncogene homolog antikoerper, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a) antikoerper, MAF antikoerper, Maf antikoerper, mafa antikoerper

Molekulargewicht: 50 kDa

NCBI Accession: NP_005351