PD-L1 Antikörper
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- Target Alle PD-L1 Antikörper anzeigen
- PD-L1 (CD274 (PD-L1))
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Reaktivität
- Maus
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Wirt
- Ratte
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Klonalität
- Monoklonal
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Konjugat
- Dieser PD-L1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS)
- Aufreinigung
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Klon
- 10F-9G2
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product PD-L1 Primärantikörper
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- Applikationshinweise
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Kommentare
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0.5 mg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, pH 7.2
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- 2-8°C
- Haltbarkeit
- 12 months
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- Target
- PD-L1 (CD274 (PD-L1))
- Andere Bezeichnung
- CD274 (PD-L1, B7-H1) (PD-L1 Produkte)
- Synonyme
- B7-H antikoerper, B7H1 antikoerper, PD-L1 antikoerper, PDCD1L1 antikoerper, PDCD1LG1 antikoerper, PDL1 antikoerper, A530045L16Rik antikoerper, B7h1 antikoerper, Pdcd1l1 antikoerper, Pdcd1lg1 antikoerper, Pdl1 antikoerper, RGD1566211 antikoerper, CD274 molecule antikoerper, CD274 antigen antikoerper, programmed cell death 1 ligand 2 antikoerper, CD274 antikoerper, Cd274 antikoerper, PDCD1LG2 antikoerper
- Hintergrund
- The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreac- tive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor's inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of ""B7"" ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell acti- vation, tolerance, and autoimmunity.The 10F.9G2 antibody may be used as a marker for PD-L1 expression on T and B cells, NK cells and on dendritic cells. It is also widely used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.
- Gen-ID
- 60533
- Pathways
- Cancer Immune Checkpoints
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