NK-1.1/CD161c Antikörper
-
- Target Alle NK-1.1/CD161c Produkte
- NK-1.1/CD161c (NK-1.1)
-
Reaktivität
- Maus
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser NK-1.1/CD161c Antikörper ist unkonjugiert
-
Applikation
- Flow Cytometry (FACS), Immunoprecipitation (IP), Immunofluorescence (IF), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Aufreinigung
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
- Endotoxin-Niveau
- Low endotoxin: < 0.01 EU/ug
- Klon
- PK136
- Isotyp
- IgG2a kappa
-
-
- Applikationshinweise
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
- Kommentare
-
2 mg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Buffer
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C
- Informationen zur Lagerung
- 2-8°C
- Haltbarkeit
- 12 months
-
- Target
- NK-1.1/CD161c (NK-1.1)
- Andere Bezeichnung
- NK1.1 (CD161) (NK-1.1/CD161c Produkte)
- Synonyme
- AI462337 antikoerper, CD161 antikoerper, Ly-59 antikoerper, Ly55c antikoerper, Ly59 antikoerper, NK-RP1 antikoerper, NK1.1 antikoerper, NKR-P1.9 antikoerper, NKRP1 antikoerper, NKRP140 antikoerper, Nk-1 antikoerper, Nk-1.2 antikoerper, Nk1 antikoerper, Nk1.2 antikoerper, Nkrp1c antikoerper, ly-55c antikoerper, killer cell lectin-like receptor subfamily B member 1C antikoerper, Klrb1c antikoerper
- Hintergrund
- The PK136 antibody is specific for mouse NK1.1, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. NK1.1 is prominently expressed on natural killer (NK) cells, and is correlated with NK cytotoxic effects toward virus-infected cells and tumor cells. NK1.1 is expressed on subsets of NKT cells in certain mouse strains (C57BL/6, FVB/N, and NZB), yet absent from others (AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129). Putative subsets of NK cells and their expression of NK1.1 antigen are of continuing interest, including NK1.1+/CD117+ (c-Kit) cells reported to be immunosuppressive for CD8+ T cells in a mechanism involving PD-1 and PD-L1. (Ehlers et al. 2012. Endocrinology. 10: 1247.)The PK136 antibody may be used for detection of NK1.1 expression on mouse strains including CE, B6, NZB, C58, Ma/My, ST, SJL, and FVB. The antibody is reported to react with an epitope common to NKR-P1B and NKR-P1C alloantigenic forms of NK1.1 (Carlyle et al. 2006. J. Immunol. 176: 7511-7524).
- Gen-ID
- 17059
- UniProt
- P27814
-