SIRPA Antikörper (AA 31-370)

Produktnummer ABIN6961045

Dieses Anti-SIRPA-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von SIRPA in FACS, ELISA, IP und IF. Geeignet für Human.

Kurzübersicht für SIRPA Antikörper (AA 31-370) (ABIN6961045)

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SIRPA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: DM8

Produktdetails anti-SIRPA Antikörper

Bindungsspezifität: AA 31-370

Aufreinigung: Purified from cell culture supernatant by affinity chromatography

Immunogen: Recombinant human SIRPalpha (Glu31-Arg370) (ABIN6961082) produced by using human HEK293 cells

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cyt  1/100, IP 1/30

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 % Glycerol, PBS, pH 7.4, 0.1 % BSA, 0.1 % Procline 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Haltbarkeit: 12 months

Details zu SIRPA

Target: SIRPA (Signal-Regulatory Protein alpha (SIRPA))

Andere Bezeichnung: SIRPalpha

Hintergrund: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.

Molekulargewicht: 55 kDa

Gen-ID: 140885

UniProt: P78324