Rekombinanter SARS-CoV-2 Nucleocapsid Antikörper (AA 1-419) (FITC)

Produktnummer ABIN6953158

Produktdetails anti-SARS-CoV-2 Nucleocapsid Antikörper (FITC)

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Antikörpertyp: Recombinant Antibody

Fragment: scFv fragment

Bindungsspezifität: AA 1-419

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Human

Klonalität: Monoklonal

Konjugat: Dieser SARS-CoV-2 Nucleocapsid Antikörper ist konjugiert mit FITC

Applikation: ELISA

Produktmerkmale: Recombinant anti-SARS-CoV-2 Nucleoprotein Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
Mouse scFv fusion with human IgG1 Fc

Aufreinigung: Affinity-chromatography

Immunogen: Recombinant Human Novel Coronavirus Nucleoprotein (N) (1-419aa)

Klon: 1A6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze

Details zu SARS-CoV-2 Nucleocapsid

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Andere Bezeichnung: SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N Produkte)

Substanzklasse: Viral Protein

Hintergrund: Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3' end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine-arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection.

UniProt: P0DTC9