Rekombinanter SARS-CoV-2 Nucleocapsid Antikörper (AA 1-419)

Produktnummer ABIN6953156

Produktdetails anti-SARS-CoV-2 Nucleocapsid Antikörper

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Antikörpertyp: Recombinant Antibody

Fragment: scFv fragment

Bindungsspezifität: AA 1-419

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Human

Klonalität: Chimeric

Konjugat: Dieser SARS-CoV-2 Nucleocapsid Antikörper ist unkonjugiert

Applikation: ELISA, Colloidal Gold Immunochromatography Assay (GICA)

Produktmerkmale: Recombinant anti-SARS-CoV-2 Nucleoprotein Mouse ScFv is expressed from 293 cells (HEK293), It is a chimeric monoclonal antibody combining the mouse variable regions with the constant domains of human IgG1.
Monoclonal mouse (varialbe region)/human (kappa/IgG1 constant)chimeric antibody

Aufreinigung: Affinity-chromatography

Immunogen: Recombinant Human Novel Coronavirus Nucleoprotein (N) (1-419aa)

Klon: 1A6

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA 1:10000-1:50000
GICA 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze

Details zu SARS-CoV-2 Nucleocapsid

Target: SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)

Andere Bezeichnung: SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N Produkte)

Synonyme: nucleocapsid phosphoprotein antikoerper, N antikoerper

Substanzklasse: Viral Protein

Hintergrund: Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3' end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine-arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection.

UniProt: P0DTC9