CBFB Antikörper

Produktnummer ABIN6952396

Dieses Anti-CBFB-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CBFB in ELISA, ChIP und ChIP-seq. Geeignet für Human.

Kurzübersicht für CBFB Antikörper (ABIN6952396)

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBFB Antikörper ist unkonjugiert

Applikation: ELISA, Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Produktdetails anti-CBFB Antikörper

Spezifität: Polyclonal antibody raised in rabbit against human CBFb (core-binding factor, beta subunit) using two KLH-conjugated synthetic peptides containing sequences from the central region of the protein.

Aufreinigung: whole antiserum

Immunogen: synthetic peptide

Anwendungsinformationen

Applikationshinweise: ChIP 4 μL:ChIP
ELISA 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: serum, 0.05 % azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu CBFB

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Andere Bezeichnung: CBFb

Hintergrund: CBFb (UniProtKB/Swiss-Prot entry Q13951) represents the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family. These transcription factors regulate a host of genes specific to haematopoiesis (e.g. RUNX1) and osteogenesis (e.g. RUNX2). The beta subunit is the regulatory subunit which allosterically enhances the activity of the DNA binding alpha subunit as the complex binds to the core site of various enhancers and promoters. CBFb can be involved in a chromosomal rearrangement of chromosome 16 (inv(16)(p13q22)) which produces a fusion protein consisting of the N terminus of CBFb and the C-terminal portion of MYH11. This chromosomal rearrangement is associated with acute myeloid leukaemia of the M4Eo subtype

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha