CBFB Antikörper

Produktnummer ABIN7252390

Produktdetails anti-CBFB Antikörper

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBFB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Full length fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CBFB

Target: CBFB (Core-Binding Factor, beta Subunit (CBFB))

Andere Bezeichnung: CBFB (CBFB Produkte)

Synonyme: PEBP2B antikoerper, Cbfb antikoerper, pebp2b antikoerper, Pebp2 antikoerper, CBFB antikoerper, unp1266 antikoerper, cbf-beta antikoerper, cbfbeta antikoerper, pea2-beta antikoerper, pebp2-beta antikoerper, AI893578 antikoerper, PEA2 antikoerper, PEBP2b antikoerper, Pebpb2 antikoerper, core-binding factor beta subunit antikoerper, core binding factor beta subunit antikoerper, core-binding factor, beta subunit antikoerper, core-binding factor, beta subunit S homeolog antikoerper, core binding factor beta antikoerper, CBFB antikoerper, Cbfb antikoerper, cbfb antikoerper, cbfb.S antikoerper

Hintergrund: The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht:

Observed_MW: Refer to figures

Calculated_MW: 22 kDa

UniProt: Q13951

Pathways: Regulation of Lipid Metabolism by PPARalpha