Polyclonal antibody raised in rabbit against human CHD1 (Chromodomain Helicase DNA Binding Protein 1), using a synthetic peptide containing a sequence from the C-terminal part of the protein.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
CHD1
(Chromodomain Helicase DNA Binding Protein 1 (CHD1))
Andere Bezeichnung
CHD1
Hintergrund
CHD1 (UniProtKB/Swiss-Prot entry O14646) functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It is required for the recognition of H3K4me3 by the FACT and PAF complexes as well as the U2 snRNP complex and regulates both polymerase II and polymerase I transcription. CHD1 further negatively regulates DNA replication and is required for maintaining open chromatin and pluripotency in embryonic stem cells.