BRD4 Antikörper (N-Term)

Produktnummer ABIN6952374

Der Kaninchen Polyklonal Anti-BRD4-Antikörper wurde für WB, ELISA, ChIP und ChIP-seq validiert. Er ist geeignet, BRD4 in Proben von Human zu detektieren.

Kurzübersicht für BRD4 Antikörper (N-Term) (ABIN6952374)

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Chromatin Immunoprecipitation (ChIP), ChIP DNA-Sequencing (ChIP-seq)

Produktdetails anti-BRD4 Antikörper

Bindungsspezifität: N-Term

Spezifität: Polyclonal antibody raised in rabbit against human BRD4 (Bromodomain Containing 4), using two KLH-conjugated synthetic peptides from the N-terminal and central part of the protein, respectively.

Aufreinigung: Peptide affinity purified

Immunogen: synthetic peptide

Anwendungsinformationen

Applikationshinweise: ChIP 2 μg:ChIP
ELISA 1:10,000
WB 1:1,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2.6 μg/μL

Buffer: PBS, 0.05 % azide, 0.05 % ProClin300

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu BRD4

Target: BRD4 (Bromodomain Containing 4 (BRD4))

Andere Bezeichnung: BRD4

Hintergrund: BRD4 (UniProt/Swiss-Prot entry O60885) is a chromatin reader protein that binds acetylated histones. It remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for gene transcription by preserving an acetylated chromatin status. As such, it plays a key role in the transmission of epigenetic memory across cell divisions. BRD4 promotes phosphorylation of Ser-2 of the C-terminal domain (CTD) of RNA polymerase II and plays a key role in regulating the transcription of signal-inducible genes. It has been implicated in a translocation of chromosome 19 which causes an upper respiratory tract carcinoma.

UniProt: O60885

Pathways: Chromatin Binding, SARS-CoV-2 Protein Interaktom