COL2 Antikörper

Produktnummer ABIN6950841

Der Maus Monoklonal anti-COL2 Antikörper wird verwendet zum Nachweis von COL2 in Proben von Human. Er wurde validiert für IHC.

Kurzübersicht für COL2 Antikörper (ABIN6950841)

Target: COL2 (Collagen, Type II (COL2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser COL2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-COL2 Antikörper

Verwendungszweck: E-Cadherin mouse mAb

Spezifität: The antibody can specifically recognize E-cadherin protein.

Aufreinigung: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 700 - 800 of the human E - Cadherin protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, 1:200-1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu COL2

Target: COL2 (Collagen, Type II (COL2))

Andere Bezeichnung: Collagen Type II

Hintergrund:

Synonyms: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin) , Uvomorulin, CD324, CDH1, CDHE

Background: E-Cadherein, 120 kDa, is a critical regulator of epithelial junction formation. The E-cadherin internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the ECAD complex to the actin cytoskeleton of the cell. E-cadherin is expressed in virtually all epithelial cells with the exception of adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells) . Mesothelial cells and granulosa cells are ECAD negative. Mesenchymal cells and neural crest cells are mostly negative but some types may show a weak reaction. Testicular germinative cells are weakly positive. At present, it is commonly used to differentiate breast lobular cancer from ductal cancer (the former is often negative, the latter is often positive) .

Gene Name: CDH1

Protein Name: E-Cadherin

Gen-ID: 999

UniProt: P12830