Rekombinanter Transferrin Receptor Antikörper (AA 100-450)
Kurzübersicht für Rekombinanter Transferrin Receptor Antikörper (AA 100-450) (ABIN6945214)
Target
Alle Transferrin Receptor (TFRC) Antikörper anzeigenAntikörpertyp
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 100-450
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Verwendungszweck
- TFRC Recombinant Antibody
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Kreuzreaktivität
- Human, Ratte
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Homologie
- Mouse
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Aufreinigung
- Purified by Protein A.
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Immunogen
- Human Transferrin Receptor between 100 to 450 amino acids
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Isotyp
- IgG
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Applikationshinweise
- WB(1:300-5000), Flow-Cyt(1:20-100), ICC/IF(1:50-100)
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- Lot specific
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Buffer
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C for 12 months.
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Haltbarkeit
- 12 months
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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Andere Bezeichnung
- Transferrin Receptor
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Hintergrund
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Synonyms: Transferrin receptor protein 1, T9, p90, CD_antigen: CD71, TR, TfR, TfR1, Trfr, TFRC
Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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UniProt
- P02786
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Pathways
- Transition Metal Ion Homeostasis
Target
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