SUN1 Antikörper

Produktnummer ABIN6945098

Dieses Anti-SUN1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von SUN1 in WB, FACS, IHC (p), IF (cc) und IF (p). Geeignet für Human und Ratte.

Kurzübersicht für SUN1 Antikörper (ABIN6945098)

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SUN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Klon: 2C4

Produktdetails anti-SUN1 Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein corresponding to C-terminal human SUN1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu SUN1

Target: SUN1 (Sad1 and UNC84 Domain Containing 1 (SUN1))

Andere Bezeichnung: SUN1

Hintergrund:

Synonyms: SUN domain-containing protein 1, Protein unc-84 homolog A, Sad1/unc-84 protein-like 1, SUN1, KIAA0810, UNC84A

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.

Gen-ID: 23353

UniProt: O94901

Pathways: Maintenance of Protein Location