Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

PABPN1 Antikörper

PABPN1 Reaktivität: Human, Maus WB, IHC (p), FACS, IF (cc), IF (p) Wirt: Kaninchen Monoclonal 1C1 unconjugated
Produktnummer ABIN6944405
  • Target Alle PABPN1 Antikörper anzeigen
    PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
    Reaktivität
    • 41
    • 19
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    Human, Maus
    Wirt
    • 41
    Kaninchen
    Klonalität
    • 31
    • 10
    Monoklonal
    Konjugat
    • 17
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PABPN1 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 13
    • 6
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus
    Aufreinigung
    Purified by Protein A.
    Immunogen
    N terminus human PABPN1
    Klon
    1C1
    Isotyp
    IgG
    Top Product
    Discover our top product PABPN1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))
    Andere Bezeichnung
    PABPN1 (PABPN1 Produkte)
    Synonyme
    OPMD antikoerper, PAB2 antikoerper, PABII antikoerper, PABP-2 antikoerper, PABP2 antikoerper, Pabp3 antikoerper, mPABII antikoerper, ARABIDOPSIS POLY(A) BINDING 2 antikoerper, ATPAB2 antikoerper, F28A23.130 antikoerper, F28A23_130 antikoerper, POLY(A) BINDING PROTEIN 2 antikoerper, POLY(A)-BINDING PROTEIN 2 antikoerper, poly(A) binding protein 2 antikoerper, opmd antikoerper, pab2 antikoerper, pabp2 antikoerper, pabpii antikoerper, pabpn1 antikoerper, Pabpn1 antikoerper, Poly(A)-binding protein 2 antikoerper, fb19c03 antikoerper, wu:fb17e03 antikoerper, wu:fb18c06 antikoerper, wu:fb19c03 antikoerper, zgc:85979 antikoerper, zgc:92452 antikoerper, poly(A) binding protein nuclear 1 antikoerper, poly(A) binding protein, nuclear 1 antikoerper, poly(A) binding protein 2 antikoerper, poly(A) binding protein, nuclear 1 S homeolog antikoerper, poly(A) binding protein, nuclear 1 L homeolog antikoerper, polyadenylate-binding protein 2 antikoerper, poly(A) binding protein Pab2 antikoerper, PABPN1 antikoerper, Pabpn1 antikoerper, PAB2 antikoerper, pabpn1.S antikoerper, pabpn1.L antikoerper, LOC100728725 antikoerper, pab2 antikoerper, pabpn1 antikoerper
    Hintergrund

    Synonyms: Polyadenylate-binding protein 2, Nuclear poly(A)-binding protein 1, Poly(A)-binding protein II, Polyadenylate-binding nuclear protein 1, PABP-2, Poly(A)-binding protein 2, PABII, PABPN1

    Background: Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes (PubMed:11371506). Binds to poly(A) and to poly(G) with high affinity (By similarity). May protect the poly(A) tail from degradation (By similarity). Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484).

    Gen-ID
    8106
    UniProt
    Q86U42
Kundenservice