MADD Antikörper (AA 851-950) (Cy7)

Produktnummer ABIN6943997

Dieses Anti-MADD-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MADD in IF (p) und IF (cc). Geeignet für Maus.

Kurzübersicht für MADD Antikörper (AA 851-950) (Cy7) (ABIN6943997)

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MADD Antikörper ist konjugiert mit Cy7

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-MADD Antikörper (Cy7)

Bindungsspezifität: AA 851-950

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DENN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MADD

Target: MADD (MAP-Kinase Activating Death Domain (MADD))

Andere Bezeichnung: MADD

Hintergrund:

Synonyms: Differentially expressed in normal and neoplastic cells, FLJ35600, IG20, Insulinoma glucagonoma clone 20, KIAA0358, MADD, MADD_HUMAN, MAP kinase-activating death domain protein, Rab3 GDP/GTP exchange factor, RAB3GEP, DENN

Background: Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gen-ID: 8567

UniProt: Q8WXG6

Pathways: Caspase Kaskade in der Apoptose